Celladix Sebum Rebalancing RX 131 Ampoule Review

At a Glance

• Made by Celladix
• Packaging Dimension: 9cm x 8cm x 5.5cm
• 30ml / 1.01 fl oz.
• Low Irritation; Dermatologically tested
• Non-comedogenic

Packaging & Design

The Celladix Sebum Rebalancing 131 Ampoule arrives with the product and an individually packaged dropper inside a box. Once assembled with the dropper, the bottle measures 4.5cm in diameter and 8cm tall, fitting comfortably in one hand. The glass container gives it noticeable heft at around 100g, making it slightly awkward to carry alongside other personal care items whilst travelling.

The semi-transparent bottle allows you to see how much product remains, which is genuinely useful for planning repurchases without having to guess based on weight alone, especially when the bottle is heavy.

Texture & Consistency

The ampoule has a slightly viscous, transparent liquid texture that flows smoothly across the skin with a slippery, watery feel. It’s not particularly remarkable in terms of consistency, sitting at a level that even those who dislike sticky products can tolerate. There’s a subtle sweet sandalwood fragrance with citrus notes in the background. The scent remains mild enough that even fragrance-sensitive users can enjoy it comfortably.

To assess suitability for oily skin, I tested oil content using blotting paper after ten minutes. No oil transferred whatsoever, confirming the formula’s lightweight nature. That should make it favorable for oily and combination skin. It penetrates gently without irritation and spreads beautifully, though the slightly bouncy finish leaves a barely detectable residue. That’s not necessarily a criticism per se, but it’s worth noting if you prefer completely clean finishes. The sensation isn’t problematic for most, but very oily skin types might find it less than ideal.

Ingredients

Niacinamide, a well-established form of vitamin B3, sits at the core of this formulation and addresses multiple acne triggers simultaneously. It calms inflammation, which means less redness, swelling, and discomfort around active breakouts. The ingredient also regulates sebum production at the source, crucial for oily skin types where excess oil creates the ideal environment for acne development.

Clinical studies show niacinamide works against Cutibacterium acnes, the bacteria responsible for inflammatory acne, without the antibiotic resistance issues that come with conventional treatments. It also strengthens the skin barrier, reduces water loss, and helps fade the dark marks that often linger after breakouts heal.

The formula reinforces these benefits with ceramide NP and beta-glucan, which work together to fortify the skin barrier and provide soothing properties. This combination proves particularly valuable for skin compromised by acne treatments or chronic inflammation. Panthenol and botanical extracts contribute additional hydration and calming effects, whilst offering antioxidant protection against environmental stressors.

However, it’s worth noting that the botanical extracts and essential oils, whilst beneficial for many, may trigger sensitivity in some users. This formulation targets mild to moderate acne and sebum regulation effectively, but severe cystic acne typically demands more aggressive medical intervention. Those with sensitive or complex acne should patch test first and consult a dermatologist if over-the-counter solutions aren’t delivering results.

Performance

Before diving into detailed observations, I just want to say that this product requires patience. This is my seventh bottle of the Celladix Sebum Rebalancing Ampoule, and it’s been almost a year since I finished the sixth.

I’ve noticed a consistent pattern whenever I start using it again: non-inflamed acne improves quickly, while inflamed acne heals more gradually as the overall skin environment adjusts. During this process, breakouts can initially appear worse, which might make some people question whether it’s really working. If you don’t use it consistently, the pattern tends to reset, as if you’re starting from the beginning, and that’s been my experience so far.

This round, I was dealing with continuous nodular and cystic acne, so I documented the entire process. The images show week one through week four. Week two and three may not look particularly severe, but the daily progression reveals acne continuously surfacing. It felt like waves churning the ocean through a purging process.

Week one presented the challenge I’d anticipated. The deep, painful lumps sitting under my skin began surfacing more aggressively. This is where some people abandon products, convinced they’re making things worse. Having been through this cycle six times before, I was used to the pattern and stuck with my routine. The nodules brewing beneath the surface were being forced to resolve rather than lingering indefinitely. By day six or seven, several had come to a head and began draining, which looked worse but felt like progress.

Week two marked a visible shift. The active inflammation from week one started calming considerably. What would normally take ten days to heal was resolving in five or six. The redness surrounding older lesions faded more quickly, and new formations weren’t developing at the same aggressive rate. My skin still looked compromised, but the trajectory had clearly changed from inflamed breakouts to surface-level healing.

Week three introduced what I’d describe as a cleanup phase. Smaller, less severe breakouts appeared sporadically, predominantly around my chin and jawline, where congestion concentrates. These weren’t the angry, inflamed lesions from week one but rather minor comedones that surfaced and resolved within two to three days. The Celadix appeared to be working through residual congestion systematically.

Week four delivered the payoff. Overall texture had improved noticeably, with post-inflammatory marks fading faster than usual. Active breakouts were minimal, and my skin tone looked more even. While I wouldn’t call the acne improvement dramatic, what genuinely impressed me was the accelerated healing cycle. Breakouts that would normally take two weeks to fully resolve were clearing in seven to ten days, and the reduced inflammation meant less severe scarring overall.

Even beyond acne management, this ampoule works exceptionally well for oily skin because it noticeably reduces sebum production. Before using this, I’d wake up with severe oil buildup that sometimes required an alkaline cleanser in the morning just to feel clean. While using this product, the problem decreased significantly. A gentle, acidic cleanser became perfectly adequate for my morning routine.

The hydration level feels precisely right for oily skin. It delivers moisture without any oil whatsoever, making it perfectly adequate as a standalone product in summer or an excellent hydrating base in other seasons. Unlike other acne treatments that strip the skin dry and force me to add extra moisturizing steps, this kept my routine simple. The only additional product I needed was a single-spot gel. Dry skin types probably won’t experience dryness, but I doubt they’d see other benefits from this product either.

Value for Money

The Celladix Sebum Rebalancing Ampoule doesn’t offer particularly strong value for money, given the small capacity and need for consistent use. The formula does soften surface-level hardened breakouts effectively, which is a clear advantage, but deep, painful, inflamed acne takes considerably longer to respond without immediate results. At this price point for this volume, that feels slightly disappointing.

That said, for extremely oily skin types seeking a balanced product that provides adequate hydration whilst controlling sebum production, the value proposition improves significantly. In other words, if you’re primarily targeting acne treatment, it feels expensive. If you’re looking for sebum control as the primary function with acne improvement and hydration as secondary benefits, it starts to feel more reasonably priced.

Who Is It For?

The Celladix Sebum Rebalancing RX 131 Ampoule is recommended for:

• Extremely oily skin types experiencing severe morning oil buildup that interferes with daily routines
• Those with mild to moderate acne willing to commit to an initial trial period
• Individuals seeking sebum regulation as the primary goal, with acne treatment as a secondary benefit
• Users comfortable with initial purging and gradual improvement timelines

Celladix Sebum Rebalancing RX 131 Ampoule: Verdict

The Celladix Sebum Rebalancing 131 Ampoule excels at sebum regulation but requires patience for acne improvement. The niacinamide formula genuinely reduces oil production, eliminating the need for harsh morning cleansers. However, expect an initial purging phase where deep congestion surfaces before improvement becomes visible. Once your skin adjusts, you’ll notice faster healing cycles, reduced inflammation, and quicker fading of post-inflammatory marks. This addresses mild to moderate breakouts systematically but won’t resolve severe cystic acne.

The price feels high given the small capacity and slow timeline. If you need rapid acne clearance, the value disappoints. For extremely oily skin struggling with persistent sebum overproduction, it becomes more justifiable since the oil control works exceptionally well. This is a targeted solution for oily skin that controls sebum production effectively while improving acne gradually. It works if you commit to the process, but it won’t deliver immediate, dramatic results.